The effect of environmental exposure on gene expression can be seen in responses to smoking, caloric restriction, certain infections, and exposure to endocrine disruptors, including bisphenol A (BPA). Studies such as the Dutch Famine studies have suggested some methylation modifications to gene expression may be heritable. Epigenetic modification in the form of histone methylation is implicated in a number of psychiatric conditions, including autism, and schizophrenia, and physiological conditions including obesity.

It’s not quite Lamarck’s giraffe stretching its neck, but Methyl-Seq and Bisulfite-Seq methods of Next Generation Sequencing have new understanding of the way the genome interacts with the environment and vice versa by allowing methylation analysis of the whole genome.

Bioo Scientific’s NEXTflex™ Methyl-Seq 1 Kit, designed to enrich and prepare single, paired-end and multiplexed methylated DNA libraries, and NEXTflex™ Bisulfite-Seq Kit, designed to work with reduced representation or total bisulfite-converted DNA libraries, enable library preparation for Illumina-compatible sequencing to examine methylation patterns in the genome.

We can’t wait to see what you uncover about the epigenome.